Destroy All Humans! is an action-adventure game for the PlayStation 4 that allows players to take on the role of Cryptosporidium 137, or Crypto, an alien tasked with invading Earth to harvest human DNA. Players use a variety of extraterrestrial weapons and psychic abilities to combat humans and government forces. The game provides a humorous take on 1950s America with satirical storytelling and parodic references to Cold War-era pop culture. It stands out for its open-world exploration, upgradeable alien arsenal, and the ability to pilot a flying saucer to wreak havoc from above.