Alien Syndrome is an action role-playing game developed by Totally Games and published by Sega for the Nintendo Wii, released in 2007. It is an update of the original 1987 arcade game by Sega. Players control Earth Command Lieutenant Aileen Harding as she battles through hordes of aliens. With cooperative gameplay, a wide array of weapons, and RPG elements such as character leveling and item customization, this sci-fi shooter offers a blend of classic arcade action and modern gaming.