Crash: Mind Over Mutant is a platforming adventure game for Microsoft Xbox 360 where players navigate as Crash Bandicoot to defeat the nefarious Dr. Neo Cortex. Cortex has invented a device that controls both mutants and Crash's friends, and Crash must free them while utilizing the abilities of various mutants. The player explores diverse environments, collects items, and combats Cortex's minions. With cooperative gameplay elements, the game emphasizes exploration, combat, and puzzle-solving, melding classic Crash gameplay with new mechanics and a humorous storyline.